Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Novel Mutation of the α2-Globin Gene Causing α+-Thalassemia: Hb Nanning (HBA2: c.369_370delinsGA).

Hemoglobin - 1 Jan 2017

Chen Biyan, Lin Li, Yi Shang, Chen Qiuli, Wei Hongwei, Li Guojian, Zheng Chenguang, He Sheng, Qiu XiaoXia

Abstract excerpt

We report a novel mutation on the α2-globin gene, Hb Nanning (HBA2:c.369_370delinsGA) detected in a Chinese family. This mutation gives rise to a previously undescribed hemoglobin (Hb) variant that was undetectable by various separation techniques. Both carriers of the mutation have mean corpuscular volume (MCV) and mean corpuscular Hb (MCH) values that are below normal, as would be predicted for an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Globins
Share to alpha-Thalassemia
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Erythrocyte Indices

Share to Hemoglobin A2

Share to Hemoglobins, Abnormal

Share to Sequence Deletion

Source

Identifiers

PMID: 28395547
DOI: 10.1080/03630269.2017.1302950

Genes

HBA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Novel Mutation of the α2-Globin Gene Causing α+-Thalassemia: Hb Nanning (HBA2: c.369_370delinsGA).PMID 28395547Read ↗

A Novel α2-Globin Gene Mutation: Hb Debao [α31(B12)Arg→Trp; HBA2: c.94A>T].Semantic proximity Read ↗

Hematological and molecular characteristics of a novel α-globin variant Hb Liangqing (HBA2:c.224A>G).Semantic proximity Read ↗

A Novel Frameshift Mutation(HBA2:C.337delC) Associated With α-Thalassemia Trait Detected by Next-Generation Sequencing in Southern China.Semantic proximity Read ↗

First Report of Nondeletional Hb H Disease Caused by an α2-Globin Gene Mutation: HBA2: c.184A>T.Semantic proximity Read ↗

First study to describe a novel HbA2: c.400A > C mutation and Hb Dongguan heterozygote in two unrelated Chinese families.Semantic proximity Read ↗

Analysis of δ-globin gene mutations in the Chinese population.Semantic proximity Read ↗

Hb Dapu (HBA2: c.52G > T): A Novel Nondeletional α-Thalassemia Mutation.Semantic proximity Read ↗

Hb A2-Guangxi [δ79 (EF3) Asp→Asn, HBD: C.238G > A] and polyA + 70 (HBD: C.*200G > A): Two Novel δ-Globin Gene Mutations Identified in a Chinese Family.Semantic proximity Read ↗

A novel mutation Hb jiangnan[β3(NA3) Leu→Lys, HBB:c.10-_11delinsAA] causing elevated Hb A2 level.Semantic proximity Read ↗

CODON 30 (-GAG) (α2): hematological parameters in heterozygotes and also patients with Hb H disease.Semantic proximity Read ↗

Mild α-Thalassemia Caused by a Mosaic α-Globin Gene Mutation.Semantic proximity Read ↗

A Novel Hemoglobin Variant Hb Liaobu [α107(G14)Val→Leu, HBA2: c.322G>C] Detected by Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.