Article
Evaluation of QTc in Rett syndrome: Correlation with age, severity, and genotype.
American journal of medical genetics. Part A - 1 Jun 2017
Crosson Jane, Srivastava Siddharth, Bibat Genila M, Gupta Siddharth, Kantipuly Aditi, Smith-Hicks Constance, Myers Scott M, Sanyal Abanti, Yenokyan Gayane, Brenner Joel, Naidu Sakkubai R
Abstract excerpt
Rett syndrome (RTT) is caused by MECP2 mutations, resulting in various neurological symptoms. Prolonged corrected QT interval (QTc) is also reported and is a speculated cause of sudden death in RTT. The purpose of this study was to correlate QTc in RTT patients with age, clinical severity, and genotype. 100 RTT patients (98 females, 2 males) with MECP2 mutations underwent baseline neurological evaluation (KKI-RTT...
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