Article
GRMD cardiac and skeletal muscle metabolism gene profiles are distinct.
BMC medical genomics - 8 Apr 2017
Markham Larry W, Brinkmeyer-Langford Candice L, Soslow Jonathan H, Gupte Manisha, Sawyer Douglas B, Kornegay Joe N, Galindo Cristi L
Abstract excerpt
BACKGROUND: Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, which codes for the dystrophin protein. While progress has been made in defining the molecular basis and pathogenesis of DMD, major gaps remain in understanding mechanisms that contribute to the marked delay in cardiac compared to skeletal muscle dysfunction. METHODS: To address this question, we analyzed cardiac and skeletal...
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