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Article

Role of the SRRz/Rz1 lambdoid lysis cassette in the pathoadaptive evolution of Shigella.

International journal of medical microbiology : IJMM - 1 Jun 2017

Leuzzi Adriano, Grossi Milena, Di Martino Maria Letizia, Pasqua Martina, Micheli Gioacchino, Colonna Bianca, Prosseda Gianni

Abstract excerpt

Shigella, the etiological agent of bacillary dysentery (shigellosis), is a highly adapted human pathogen. It evolved from an innocuous ancestor resembling the Escherichia coli strain by gain and loss of genes and functions. While the gain process concerns the acquisition of the genetic determinants of virulence, the loss is related to the adaptation of the genome to the new pathogenic status and occurs by...

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PMID: 28389211
DOI: 10.1016/j.ijmm.2017.03.002

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