Article
Sequential recruitment of study participants may inflate genetic heritability estimates.
Human genetics - 1 Jun 2017
Noce Damia, Gögele Martin, Schwienbacher Christine, Caprioli Giulia, De Grandi Alessandro, Foco Luisa, Platzgummer Stefan, Pramstaller Peter P, Pattaro Cristian
Abstract excerpt
After the success of genome-wide association studies to uncover complex trait loci, attempts to explain the remaining genetic heritability (h 2) are mainly focused on unraveling rare variant associations and gene-gene or gene-environment interactions. Little attention is paid to the possibility that h 2 estimates are inflated as a consequence of the epidemiological study design. We studied the time series of 54...
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