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TM4SF1 Promotes Metastasis of Pancreatic Cancer via Regulating the Expression of DDR1

3 Apr 2017

Abstract excerpt

Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. However, the TM4SF1-associated signaling network in metastasis remains unknown. In the present study, we found that TM4SF1 affected the formation and function of invadopodia. Silencing of TM4SF1 reduced the expression of DDR1 significantly...

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PMID: 28368050
DOI: 10.1038/srep45895

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