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Article

Testicular organoid generation by a novel in vitro three-layer gradient system

23 Mar 2017

Abstract excerpt

A system that models the testicular microenvironment and spermatogonial stem-cell (SSC) niche in vitro has not been produced yet. Here, we developed and characterized a novel three-dimensional multilayer model, the Three-Layer Gradient System (3-LGS), which permits the generation of rat testicular organoids with a functional blood-testis barrier (BTB) and germ cell establishment and proliferation. The model is...

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PMID: 28364632
DOI: 10.1016/j.biomaterials.2017.03.025

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