Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intracerebroventricular Delivery in Mice for Motor Neuron Diseases.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Nizzardo M, Rizzuti M

Abstract excerpt

The use of antisense oligonucleotides to target specific mRNA sequences represents a promising therapeutic strategy for neurological disorders. Recent advances in antisense technology enclose the development of phosphorodiamidate morpholino oligomers (MO), which is one of the best candidates for molecular therapies due to MO's excellent pharmacological profile.Nevertheless, the route of administration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Gene Transfer Techniques
Share to Genetic Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Morpholinos

Share to Motor Neuron Disease

Share to Motor Neurons

Share to Superoxide Dismutase-1

Share to Survival of Motor Neuron 2 Protein

Source

Identifiers

PMID: 28364247
DOI: 10.1007/978-1-4939-6817-6_19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intracerebroventricular Delivery in Mice for Motor Neuron Diseases.PMID 28364247Read ↗

Systemic and ICV Injections of Antisense Oligos into SMA Mice and Evaluation.Semantic proximity Read ↗

Effect of combined systemic and local morpholino treatment on the spinal muscular atrophy Δ7 mouse model phenotype.Semantic proximity Read ↗

Cell-penetrating peptide-conjugated Morpholino rescues SMA in a symptomatic preclinical model.Semantic proximity Read ↗

DG9-conjugated morpholino rescues phenotype in SMA mice by reaching the CNS via a subcutaneous administration.Semantic proximity Read ↗

Emerging Perspectives on Gene Therapy Delivery for Neurodegenerative and Neuromuscular DisordersSemantic proximity Read ↗

A single administration of morpholino antisense oligomer rescues spinal muscular atrophy in mouseSemantic proximity Read ↗

Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular AtrophySemantic proximity Read ↗

DG9-Conjugated Morpholino Rescues Phenotype in Spinal Muscular Atrophy Mice.Semantic proximity Read ↗

Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy.Semantic proximity Read ↗

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy.Semantic proximity Read ↗

AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trialsSemantic proximity Read ↗

Identification of a Peptide for Systemic Brain Delivery of a Morpholino Oligonucleotide in Mouse Models of Spinal Muscular Atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.