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Estrogen signaling, through estrogen receptor β, regulates DNA methylation and its machinery in male germ line in adult rats

31 Mar 2017

Abstract excerpt

Estrogen, through its receptors, regulates various aspects of spermatogenesis and male fertility. To understand the roles of estrogen receptors (ERα and ERβ) in male fertility, we have developed in vivo selective ER agonist administration models. Treatment of adult male rats with ERα or ERβ agonist for 60 d decreases fertility and litter size mainly due to increased pre- and post-implantation embryo loss. Since...

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PMID: 28362134
DOI: 10.1080/15592294.2017.1309489

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