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Article

Bacterial clonal diagnostics as a tool for evidence-based empiric antibiotic selection.

PloS one - 1 Jan 2017

Tchesnokova Veronika, Avagyan Hovhannes, Rechkina Elena, Chan Diana, Muradova Mariya, Haile Helen Ghirmai, Radey Matthew, Weissman Scott, Riddell Kim, Scholes Delia, Johnson James R, Sokurenko Evgeni V

Abstract excerpt

Despite the known clonal distribution of antibiotic resistance in many bacteria, empiric (pre-culture) antibiotic selection still relies heavily on species-level cumulative antibiograms, resulting in overuse of broad-spectrum agents and excessive antibiotic/pathogen mismatch. Urinary tract infections (UTIs), which account for a large share of antibiotic use, are caused predominantly by Escherichia coli, a highly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

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Share to Trimethoprim, Sulfamethoxazole Drug Combination

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Source

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Identifiers

PMID: 28350870
DOI: 10.1371/journal.pone.0174132
PMCID: PMC5369764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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