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Article

Interferon-α drives monocyte gene expression in chronic unsuppressed HIV-1 infection

21 May 2010

Abstract excerpt

OBJECTIVES: HIV-1 infection dysregulates the innate immune system and alters leukocyte-gene expression. The objectives were two fold: to characterize the impact of HIV-1 infection on peripheral monocyte gene expression and to identify the predominant factor(s) responsible for altered gene expression. DESIGN AND METHODS: In a cross-sectional study (n = 55), CD14 monocytes were isolated from 11 HIV-1 seronegative...

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PMID: 20495440
DOI: 10.1097/qad.0b013e32833ac623

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