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Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53.

Pathology oncology research : POR - 1 Jan 2018

He Tianli, Guo Jiayou, Song Hongmei, Zhu Hongcheng, Di Xiaoke, Min Hua, Wang Yuandong, Chen Guangzong, Dai Wangshu, Ma Jianhua, Sun Xinchen, Ma Jianxin

Abstract excerpt

Murine double minute 2 (MDM2) negatively regulates the activity of the p53 protein and plays a vital role in cell cycle arrest, apoptosis, and senescence mediated by p53. Nutlin-3, an antagonist of MDM2, is frequently used in anti-cancer studies. In many human tumors, nutlin-3 stabilizes p53 status and enhances p53 expression in cells with wild-type p53. However, the effect of nutlin-3 combined with radiotherapy...

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Identifiers

PMID: 28341911
DOI: 10.1007/s12253-017-0215-5

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MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53.PMID 28341911Read ↗

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