Article
Lack of association of mortalin (HSPA9) and other mitochondria-related genes with risk of Parkinson's and Alzheimer's diseases.
Neurobiology of aging - 1 Jan 2017
Chung Sun Ju, Kim Mi-Jung, Ryu Ho-Sung, Kim Juyeon, Kim Young Jin, Kim Kiju, You Sooyeoun, Kim Seong Yoon, Lee Jae-Hong
Abstract excerpt
We investigated the role of mortalin (HSPA9) and its interaction with other mitochondria-related genes (parkin, PINK1, DJ1, and COQ2) as a risk factor for Parkinson's disease (PD) and Alzheimer's disease (AD) in 500 PD, 400 AD, and 500 control subjects. The HSPA9 variants identified by direct sequencing or its interaction with other genes assessed by genetic risk scores did not show a significant association with...
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