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Article

p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.

International journal of oncology - 1 May 2017

Devor Eric J, Gonzalez-Bosquet Jesus, Warrier Akshaya, Reyes Henry D, Ibik Nonye V, Schickling Brandon M, Newtson Andreea, Goodheart Michael J, Leslie Kimberly K

Abstract excerpt

Placenta-specific protein 1 (PLAC1) expression is co-opted in numerous human cancers. As a consequence of PLAC1 expression, tumor cells exhibit enhanced proliferation and invasiveness. This characteristic is associated with increased aggressiveness and worse patient outcomes. Recently, the presence of the tumor suppressor p53 was shown in vitro to inhibit PLAC1 transcription by compromising the P1, or...

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Share to Cystadenocarcinoma, Serous
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Ovarian Neoplasms

Share to Pregnancy

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 28339050
DOI: 10.3892/ijo.2017.3931
PMCID: PMC5403493

Genes

PLAC1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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