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Article

PLAC1 augments the malignant phenotype of cervical cancer through the mTOR/HIF-1α/Snail signaling pathway.

Life sciences - 15 Dec 2024

Chen Rujun, Hou Yue, Chen Jina, Dong Fuyun, Wang Xiaoqin, Guan Junhua, Zhang Liwen, Fei He, Yang Lina

Abstract excerpt

AIMS: This study investigated the molecular mechanisms of placenta-specific protein 1 (PLAC1) in cervical cancer (CCa), aiming to elucidate its role in tumorigenesis through in vitro and in vivo experiments. MATERIALS AND METHODS: CCa cell lines with overexpressed or silenced PLAC1 were established to evaluate its impact on cell cycle, apoptosis and the expression of key proteins in the PLAC1/mTOR/HIF-1α/Snail...

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Identifiers

PMID: 39549936
DOI: 10.1016/j.lfs.2024.123242

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