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Article

TDP-43 suppresses tau expression via promoting its mRNA instability

6 Mar 2017

Abstract excerpt

In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here, we investigated the role of TDP-43 in tau expression in vitro and in vivo. We found that TDP-43 suppressed tau expression...

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PMID: 28335005
DOI: 10.1093/nar/gkx175

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