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Article

Testing the Ret and Sema3d genetic interaction in mouse enteric nervous system development.

Human molecular genetics - 15 May 2017

Kapoor Ashish, Auer Dallas R, Lee Dongwon, Chatterjee Sumantra, Chakravarti Aravinda

Abstract excerpt

For most multigenic disorders, clinical manifestation (penetrance) and presentation (expressivity) are likely to be an outcome of genetic interaction between multiple susceptibility genes. Here, using gene knockouts in mice, we evaluated genetic interaction between loss of Ret and loss of Sema3d, two Hirschsprung disease susceptibility genes. We intercrossed Ret and Sema3d double null heterozygotes to generate...

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Source

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Identifiers

PMID: 28334784
DOI: 10.1093/hmg/ddx084
PMCID: PMC6075580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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