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Article

Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.

Human reproduction (Oxford, England) - 1 Apr 2017

Uimari Outi, Rahmioglu Nilufer, Nyholt Dale R, Vincent Katy, Missmer Stacey A, Becker Christian, Morris Andrew P, Montgomery Grant W, Zondervan Krina T

Abstract excerpt

Study question: Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis? Summary answer: GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28333195
DOI: 10.1093/humrep/dex024
PMCID: PMC5400041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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