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Article

Effects of miR-145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K/AKT pathways.

Cancer medicine - 1 Apr 2017

Liu Sha, Gao Guozhen, Yan Dexiong, Chen Xiangjun, Yao Xingwei, Guo Shuzhong, Li Guirong, Zhao Yu

Abstract excerpt

We aimed to detect the effects of miR-145-5p on the cell proliferation, apoptosis, migration, and invasion in NRAS-mutant, BRAF-mutant, and wild-type melanoma cells, in order to figure out the potential mechanisms and provide a novel therapeutic target of melanoma. RT-qPCR and western blot were used to detect the expression of miR-145-5p and NRAS in melanoma tumor tissues and cells, respectively. Luciferase assay...

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Source

Open in PubMed Open full text

Identifiers

PMID: 28332309
DOI: 10.1002/cam4.1030
PMCID: PMC5387172

Genes

NRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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