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Article

TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease.

The Journal of clinical endocrinology and metabolism - 1 Jun 2017

Melo Miguel, Gaspar da Rocha Adriana, Batista Rui, Vinagre João, Martins Maria João, Costa Gracinda, Ribeiro Cristina, Carrilho Francisco, Leite Valeriano, Lobo Cláudia, Cameselle-Teijeiro José Manuel, Cavadas Bruno, Pereira Luísa, Sobrinho-Simões Manuel, Soares Paula

Abstract excerpt

Context: Little is known about the frequency of key mutations in thyroid cancer metastases and its relationship with the primary tumor genotype. Objectives: To evaluate the frequency of TERT promoter (TERTp), BRAF, and NRAS mutations in metastatic thyroid carcinomas, analyzing primary thyroid tumors, lymph node metastases (LNMs), and distant metastases. Design and Patients: Mutation analysis was performed in 437...

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Source

Identifiers

PMID: 28323937
DOI: 10.1210/jc.2016-2785

Genes

BRAF
NRAS
TERT

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