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Article

C9orf72 hexanucleotide repeat expansions are not a common cause of obsessive-compulsive disorder.

Journal of the neurological sciences - 15 Apr 2017

Arthur Karissa C, Rivera Alberto M, Samuels Jack, Wang Ying, Grados Marco, Goes Fernando S, Maher Brion, Nestadt Gerald, Traynor Bryan J

Abstract excerpt

Obsessive-compulsive disorder (OCD) is a polygenic neuropsychiatric disorder characterized by repetitive thoughts and behaviors that cause distress. The pathogenic repeat expansion [GGGGCC]n found at the C9orf72 locus is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), and has also been documented in patients with psychosis and schizophrenia. Furthermore, obsessions...

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Identifiers

PMID: 28320191
DOI: 10.1016/j.jns.2017.01.040
PMCID: PMC5800785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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