Article
Global MicroRNA Expression Profiling Identifies Unique MicroRNA Pattern of Radioresistant Glioblastoma Cells.
Anticancer research - 1 Mar 2017
Ondracek Jakub, Fadrus Pavel, Sana Jiri, Besse Andrej, Loja Tomas, Vecera Marek, Radova Lenka, Smrcka Martin, Slampa Pavel, Slaby Ondrej
Abstract excerpt
Glioblastoma multiforme (GBM) is the most aggressive intracranial tumor characterized with infaust prognosis. Despite advances in neurosurgical and radiotherapeutic techniques and chemotherapy, the median overall survival ranges between 12-15 months from diagnosis. The main cause of treatment failure is considered the presence of tumor cells resistant to conventional therapy, mainly radiotherapy. MicroRNAs...
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