Article
Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
Lombardi Gemma, Berti Valentina, Tedde Andrea, Bagnoli Silvia, Piaceri Irene, Polito Cristina, Lucidi Giulia, Ferrari Camilla, Ginestroni Andrea, Moretti Marco, Pupi Alberto, Nacmias Benedetta, Sorbi Sandro
Abstract excerpt
According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy. We describe a case of dementia clinically compatible with frontotemporal dementia in an APP Ala713Thr mutation carrier in which both [18F]Florbetapir PET uptake and Aβ1-42 cerebrospinal fluid levels were normal. Further evidences are required to establish if this association is only...
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