Article
Mendelian Genes and Risk of Intracerebral Hemorrhage and Small-Vessel Ischemic Stroke in Sporadic Cases.
Stroke - 1 Aug 2017
Chong Michael, O'Donnell Martin, Thijs Vincent, Dans Antonio, López-Jaramillo Patricio, Gómez-Arbeláez Diego, Mondo Charles, Czlonkowska Anna, Skowronska Marta, Oveisgharan Shahram, Yusuf Salim, Paré Guillaume
Abstract excerpt
BACKGROUND AND PURPOSE: Mendelian strokes are rare genetic disorders characterized by early-onset small-vessel stroke. Although extensively studied among families with syndromic features, whether these genes affect risk among sporadic cases is unknown. METHODS: We sequenced 8 genes responsible for Mendelian stroke in a case-control study of sporadic stroke cases (≤70 years). Participants included 1251 primary...
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