Article
Subgroup detection in genotype data using invariant coordinate selection.
BMC bioinformatics - 16 Mar 2017
Fischer Daniel, Honkatukia Mervi, Tuiskula-Haavisto Maria, Nordhausen Klaus, Cavero David, Preisinger Rudolf, Vilkki Johanna
Abstract excerpt
BACKGROUND: The current gold standard in dimension reduction methods for high-throughput genotype data is the Principle Component Analysis (PCA). The presence of PCA is so dominant, that other methods usually cannot be found in the analyst's toolbox and hence are only rarely applied. RESULTS: We present a modern dimension reduction method called 'Invariant Coordinate Selection' (ICS) and its application to...
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