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Polyomavirus microRNAs circulating in biological fluids during viral persistence

10 Mar 2017

Abstract excerpt

Increasing evidence suggests that microRNA-mediated gene silencing, detected during exosome intercellular communication between cells, may be exploited by persistent human viruses. Recently, it has been reported that human polyomaviruses encode microRNAs that downregulate large T expression and target host factors, helping the virus to escape immune elimination. Consequently, viral microRNAs and their genetic...

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PMID: 28295832
DOI: 10.1002/rmv.1927

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