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Article

Bacterial magnetic particles improve testes-mediated transgene efficiency in mice.

Drug delivery - 1 Nov 2017

Wang Chao, Sun Guanghong, Wang Ye, Kong Nana, Chi Yafei, Yang Leilei, Xin Qiliang, Teng Zhen, Wang Xu, Wen Yujun, Li Ying, Xia Guoliang

Abstract excerpt

Nano-scaled materials have been proved to be ideal DNA carriers for transgene. Bacterial magnetic particles (BMPs) help to reduce the toxicity of polyethylenimine (PEI), an efficient gene-transferring agent, and assist tissue transgene ex vivo. Here, the effectiveness of the BMP-PEI complex-conjugated foreign DNAs (BPDs) in promoting testes-mediated gene transfer (TMGT) in mouse was compared with that of...

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Identifiers

PMID: 28283003
DOI: 10.1080/10717544.2017.1293195
PMCID: PMC8241085

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