Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice.

doi:10.1016/j.chom.2017.02.020

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Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice.

Cell host & microbe - 8 Mar 2017

Engels Géraldine, Hierweger Alexandra Maximiliane, Hoffmann Julia, Thieme René, Thiele Swantje, Bertram Stephanie, Dreier Carola, Resa-Infante Patricia, Jacobsen Henning, Thiele Kristin, Alawi Malik, Indenbirken Daniela, Grundhoff Adam, Siebels Svenja, Fischer Nicole, Stojanovska Violeta, Muzzio Damián, Jensen Federico, Karimi Khalil, Mittrücker Hans-Willi, Arck Petra Clara, Gabriel Gülsah

Abstract excerpt

Pregnant women are at high risk for severe influenza disease outcomes, yet insights into the underlying mechanisms are limited. Here, we present models of H1N1 infection in syngenic and allogenic pregnant mice; infection in the latter mirrors the severe course of 2009 pandemic influenza in pregnant women. We found that the anti-viral immune response in the pregnant host was significantly restricted as compared to...

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PMID: 28279344
DOI: 10.1016/j.chom.2017.02.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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