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Article

Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

9 Mar 2017

Abstract excerpt

BACKGROUND: Imiquimod (IMQ) produces a cutaneous phenotype in mice frequently studied as an acute model of human psoriasis. Whether this phenotype depends on strain or sex has never been systematically investigated on a large scale. Such effects, however, could lead to conflicts among studies, while further impacting study outcomes and efforts to translate research findings. METHODS: RNA-seq was used to evaluate...

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PMID: 28279190
DOI: 10.1186/s13073-017-0415-3

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