Article
Direct-Acting Antiviral Therapy Restores Immune Tolerance to Patients With Hepatitis C Virus-Induced Cryoglobulinemia Vasculitis.
Gastroenterology - 1 Jun 2017
Comarmond Cloé, Garrido Marlène, Pol Stanislas, Desbois Anne-Claire, Costopoulos Myrto, Le Garff-Tavernier Magali, Si Ahmed Si Nafa, Alric Laurent, Fontaine Hélène, Bellier Bertrand, Maciejewski Anna, Rosenzwajg Michelle, Klatzmann David, Musset Lucile, Poynard Thierry, Cacoub Patrice, Saadoun David
Abstract excerpt
BACKGROUND & AIMS: Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus-induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechanisms of these drugs and their effects on cellular immunity. METHODS: We performed a prospective study of 27 consecutive patients with HCV-CV...
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