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Article

Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.

The Journal of biological chemistry - 28 Apr 2017

Xu Jie, McPherson Peter S

Abstract excerpt

The Rab family of small GTPases functions in multiple aspects of cellular membrane trafficking. Proteins bearing a differentially expressed in normal and neoplastic cells (DENN) domain have emerged as the largest family of Rab-activating guanine nucleotide exchange factors (GEFs). Rab12 functions in the initiation of starvation-induced autophagy, and our previous work revealed that its activator, DENN...

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Identifiers

PMID: 28249939
DOI: 10.1074/jbc.M116.772434
PMCID: PMC5409492

Genes

DENND3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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