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Article

Proliferation Markers Are Associated with MET Expression in Hepatocellular Carcinoma and Predict Tivantinib Sensitivity In Vitro

28 Feb 2017

Abstract excerpt

Abstract Purpose: Tivantinib was initially reported as a selective MET inhibitor and is under phase III evaluation in "MET-high" hepatocellular carcinoma (HCC) patients. However, it has been also proposed as an antimitotic agent. We aimed to evaluate the antitumor effect of tivantinib in HCC cells by combining pharmacologic and molecular profiling. Experimental Design: Sensitivity to tivantinib, JNJ-38877605,...

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PMID: 28246274
DOI: 10.1158/1078-0432.ccr-16-3118

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