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Article

Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development

14 Mar 2018

Abstract excerpt

BACKGROUND: Hepatocyte-based metacestode culture is an attractive method to study alveolar echinococcosis (AE), but it is limited by the relatively short lifespan of cultured hepatocytes in maintaining their normal function. METHODOLOGY/PRINCIPAL FINDINGS: We describe a three-dimensional (3D) hepatic culture system developed from co-cultured hepatocytes and mesenchymal stem cells using a collagen scaffold to...

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PMID: 29538424
DOI: 10.1371/journal.pntd.0006309

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