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Article

HLA-DQ β1 alleles associated with Epstein-Barr virus (EBV) infectivity and EBV gp42 binding to cells.

JCI insight - 23 Feb 2017

Li Qingxue, Bu Wei, Gabriel Erin, Aguilar Fiona, Hoshino Yo, Miyadera Hiroko, Hess Christoph, Hornung Ronald L, Roy Amitava, Cohen Jeffrey I

Abstract excerpt

Epstein-Barr virus (EBV) infects B cells and ~95% of adults are infected. EBV glycoprotein gp42 is essential for entry of virus into B cells. EBV gp42 binds to the β1 chain of HLA-DQ, -DR, and -DP on B cells, and uses these molecules for infection. To investigate if certain HLA-DQ alleles are associated with EBV seronegativity, we recruited ~3,300 healthy adult blood donors, identified 106 EBV-seronegative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28239644
DOI: 10.1172/jci.insight.85687
PMCID: PMC5313076

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