Article
Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded Kv11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia.
Circulation - 2 May 2017
Hyltén-Cavallius Louise, Iepsen Eva W, Wewer Albrechtsen Nicolai J, Svendstrup Mathilde, Lubberding Anniek F, Hartmann Bolette, Jespersen Thomas, Linneberg Allan, Christiansen Michael, Vestergaard Henrik, Pedersen Oluf, Holst Jens J, Kanters Jørgen K, Hansen Torben, Torekov Signe S
Abstract excerpt
BACKGROUND: Loss-of-function mutations in hERG (encoding the Kv11.1 voltage-gated potassium channel) cause long-QT syndrome type 2 (LQT2) because of prolonged cardiac repolarization. However, Kv11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, insulin, and the incretins glucagon-like peptide-1 (GLP-1) and GIP (glucose-dependent insulinotropic polypeptide),...
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