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Article

The Structure of Human Parechovirus 1 Reveals an Association of the RNA Genome with the Capsid

19 Nov 2015

Abstract excerpt

UNLABELLED: Parechoviruses are human pathogens that cause diseases ranging from gastrointestinal disorders to encephalitis. Unlike those of most picornaviruses, parechovirus capsids are composed of only three subunits: VP0, VP1, and VP3. Here, we present the structure of a human parechovirus 1 (HPeV-1) virion determined to a resolution of 3.1 Å. We found that interactions among pentamers in the HPeV-1 capsid are...

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PMID: 26581987
DOI: 10.1128/jvi.02346-15

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