Article
Fallacy of the Unique Genome: Sequence Diversity within Single Helicobacter pylori Strains.
mBio - 21 Feb 2017
Draper Jenny L, Hansen Lori M, Bernick David L, Abedrabbo Samar, Underwood Jason G, Kong Nguyet, Huang Bihua C, Weis Allison M, Weimer Bart C, van Vliet Arnoud H M, Pourmand Nader, Solnick Jay V, Karplus Kevin, Ottemann Karen M
Abstract excerpt
Many bacterial genomes are highly variable but nonetheless are typically published as a single assembled genome. Experiments tracking bacterial genome evolution have not looked at the variation present at a given point in time. Here, we analyzed the mouse-passaged Helicobacter pylori strain SS1 and its parent PMSS1 to assess intra- and intergenomic variability. Using high sequence coverage depth and experimental...
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