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Article

A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.

Circulation research - 12 May 2017

Stallmeyer Birgit, Kuß Johanna, Kotthoff Stefan, Zumhagen Sven, Vowinkel Kirsty, Rinné Susanne, Matschke Lina A, Friedrich Corinna, Schulze-Bahr Ellen, Rust Stephan, Seebohm Guiscard, Decher Niels, Schulze-Bahr Eric

Abstract excerpt

RATIONALE: Familial sinus node and atrioventricular conduction dysfunction is a rare disorder that leads to paroxysmal dizziness, fatigue, and syncope because of a temporarily or permanently reduced heart rate. To date, only a few genes for familial sinus and atrioventricular conduction dysfunction are known, and the majority of cases remain pathogenically unresolved. OBJECTIVE: We aim to identify the disease...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28219978
DOI: 10.1161/CIRCRESAHA.116.310112

Genes

GNB2
HCN2
HCN4

Variants

Provenance

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