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Article

The skin barrier function gene SPINK5 is associated with challenge-proven IgE-mediated food allergy in infants.

Allergy - 1 Sept 2017

Ashley S E, Tan H-T T, Vuillermin P, Dharmage S C, Tang M L K, Koplin J, Gurrin L C, Lowe A, Lodge C, Ponsonby A-L, Molloy J, Martin P, Matheson M C, Saffery R, Allen K J, Ellis J A, Martino D

Abstract excerpt

BACKGROUND: A defective skin barrier is hypothesized to be an important route of sensitization to dietary antigens and may lead to food allergy in some children. Missense mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) skin barrier gene have previously been associated with allergic conditions. OBJECTIVE: To determine whether genetic variants in and around SPINK5 are associated with IgE-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28213955
DOI: 10.1111/all.13143

Genes

SPINK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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