Article
Neutral aggregation in finite-length genotype space.
Physical review. E - 1 Jan 2017
Houchmandzadeh Bahram
Abstract excerpt
The advent of modern genome sequencing techniques allows for a more stringent test of the neutrality hypothesis of Darwinian evolution, where all individuals have the same fitness. Using the individual-based model of Wright and Fisher, we compute the amplitude of neutral aggregation in the genome space, i.e., the probability of finding two individuals at genetic (Hamming) distance k as a function of the genome...
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