Maintenance of polymorphism, notably by net deleterious mutations, under the joint fluctuation of demography and selection in age-structured populations.

Abstract excerpt

How non-neutral genetic variation is maintained in natural populations is a fundamental question in evolutionary biology. With environmental fluctuations, the effect of a mutant allele on fitness may also fluctuate between beneficial and deleterious relative to the wild-type allele. If this fitness fluctuation is specific to individuals of a certain stage or age in the life cycle, negative frequency-dependent...

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