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Article

Genetic risk models: Influence of model size on risk estimates and precision.

Genetic epidemiology - 1 May 2017

Shan Ying, Tromp Gerard, Kuivaniemi Helena, Smelser Diane T, Verma Shefali S, Ritchie Marylyn D, Elmore James R, Carey David J, Conley Yvette P, Gorin Michael B, Weeks Daniel E

Abstract excerpt

Disease risk estimation plays an important role in disease prevention. Many studies have found that the ability to predict risk improves as the number of risk single-nucleotide polymorphisms (SNPs) in the risk model increases. However, the width of the confidence interval of the risk estimate is often not considered in the evaluation of the risk model. Here, we explore how the risk and the confidence interval...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28198095
DOI: 10.1002/gepi.22035
PMCID: PMC5628612

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