Article
Growth plate extracellular matrix-derived scaffolds for large bone defect healing.
European cells & materials - 14 Feb 2017
Cunniffe G M, Díaz-Payno P J, Ramey J S, Mahon O R, Dunne A, Thompson E M, O'Brien F J, Kelly D J
Abstract excerpt
Limitations associated with demineralised bone matrix and other grafting materials have motivated the development of alternative strategies to enhance the repair of large bone defects. The growth plate (GP) of developing limbs contain a plethora of growth factors and matrix cues which contribute to long bone growth, suggesting that biomaterials derived from its extracellular matrix (ECM) may be uniquely suited to...
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