Article

How much do model organism phenotypes contribute to the computational identification of human disease genes?

2021-12-24

Abstract excerpt

<h4>ABSTRACT</h4> Computing phenotypic similarity has been shown to be useful in identification of new disease genes and for rare disease diagnostic support. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data to greatly increase genome coverage. Work over the past decade has demonstrated the power of cross-species phenotype comparisons, and several cross-specie...

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Literature Corpus work: 897a1d71-97b7-5597-9867-3d67a925e0cd
DOI: 10.1101/2021.12.24.474099

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