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ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib

6 Feb 2017

Abstract excerpt

The ataxia telangiectasia mutated (ATM) protein kinase plays a central role in the cellular response to DNA damage. Loss or inactivation of both copies of the ATM gene (ATM) leads to ataxia telangiectasia, a devastating childhood condition characterized by neurodegeneration, immune deficiencies, and cancer predisposition. ATM is also absent in approximately 40% of mantle cell lymphomas (MCLs), and we previously...

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PMID: 28182994
DOI: 10.1016/j.tranon.2017.01.007

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