Article
Perampanel in 12 patients with Unverricht-Lundborg disease.
Epilepsia - 1 Apr 2017
Crespel Arielle, Gelisse Philippe, Tang Ngoc Phuong Loc, Genton Pierre
Abstract excerpt
OBJECTIVE: Perampanel (PER) was used in 12 patients with Unverricht-Lundborg disease (ULD) to evaluate its efficacy against myoclonus and seizures. METHODS: We treated 11 patients with EPM1 mutations (6 F, 5 M, aged 13-62 years) and a 43-year-old man with de novo KCNC1 mutation. PER was introduced by 2 mg steps at 2-4 week intervals until 6 mg/day, with a possible dose reduction or dose increase. RESULTS: Ten...
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