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Article

KLF13 is a genetic modifier of the Holt-Oram syndrome gene TBX5.

Human molecular genetics - 1 Mar 2017

Darwich Rami, Li Wenjuan, Yamak Abir, Komati Hiba, Andelfinger Gregor, Sun Kun, Nemer Mona

Abstract excerpt

TBX5, a member of the T-box family of transcription factors, is a dosage sensitive regulator of heart development. Mutations in TBX5 are responsible for Holt-Oram Syndrome, an autosomal dominant disease with variable and partially penetrant cardiac defects suggestive of the existence of genetic and environmental modifiers. KLF13, a member of the Krüppel-like family of zinc finger proteins is co-expressed with...

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Share to Heart Atria
Share to Heart Defects, Congenital
Share to Heart Septal Defects, Atrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Ventricles

Share to Kruppel-Like Transcription Factors

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Share to T-Box Domain Proteins

Share to Upper Extremity Deformities, Congenital

Source

Identifiers

PMID: 28164238
DOI: 10.1093/hmg/ddx009

Genes

TBX5
KLF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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