Article
High virulence sub-populations in Pseudomonas aeruginosa long-term cystic fibrosis airway infections.
BMC microbiology - 3 Feb 2017
O'Brien Siobhán, Williams David, Fothergill Joanne L, Paterson Steve, Winstanley Craig, Brockhurst Michael A
Abstract excerpt
BACKGROUND: Pseudomonas aeruginosa typically displays loss of virulence-associated secretions over the course of chronic cystic fibrosis infections. This has led to the suggestion that virulence is a costly attribute in chronic infections. However, previous reports suggest that overproducing (OP) virulent pathotypes can coexist with non-producing mutants in the CF lung for many years. The consequences of such...
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