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Article

Contribution to Clostridium Difficile Transmission of Symptomatic Patients With Toxigenic Strains Who Are Fecal Toxin Negative.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 May 2017

Mawer Damian P C, Eyre David W, Griffiths David, Fawley Warren N, Martin Jessica S H, Quan T Phuong, Peto Timothy E A, Crook Derrick W, Walker A Sarah, Wilcox Mark H

Abstract excerpt

Background: The role of symptomatic patients who are toxigenic strain positive (TS+) but fecal toxin negative (FT-) in transmission of Clostridium difficile is currently unknown. Methods: We investigated the contribution of symptomatic TS+/FT- and TS+/FT+ patients in C. difficile transmission in 2 UK regions. From 2-step testing, all glutamate dehydrogenase (GDH)-positive specimens, regardless of fecal toxin...

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PMID: 28158441
DOI: 10.1093/cid/cix079
PMCID: PMC5850559

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