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Article

Oral Tolerance Induction in Hemophilia B Dogs Fed with Transplastomic Lettuce.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Feb 2017

Herzog Roland W, Nichols Timothy C, Su Jin, Zhang Bei, Sherman Alexandra, Merricks Elizabeth P, Raymer Robin, Perrin George Q, Häger Mattias, Wiinberg Bo, Daniell Henry

Abstract excerpt

Anti-drug antibodies in hemophilia patients substantially complicate treatment. Their elimination through immune tolerance induction (ITI) protocols poses enormous costs, and ITI is often ineffective for factor IX (FIX) inhibitors. Moreover, there is no prophylactic ITI protocol to prevent anti-drug antibody (ADA) formation. Using general immune suppression is problematic. To address this urgent unmet medical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28153098
DOI: 10.1016/j.ymthe.2016.11.009
PMCID: PMC5368425

Genes

ADA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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